Pathologic results of intestinal polyps suggest high-grade endothelial neoplasia, which is highly suggestive of precancerous lesions and requires regular follow-up colonoscopy. Polyps take biopsy, for suspected malignancy, usually take a small portion of tissue for pathology biopsy first, and then take the next step after the results come out. High-grade intraepithelial neoplasia refers to severe atypical hyperplasia, which is actually carcinoma in situ, meaning that the tumor found has actually developed early cancerous changes, but has not yet infiltrated. It is necessary to go to the gastrointestinal surgery or gastroenterology department for consultation, so that the doctor can interpret and decide the next treatment plan; if it is the result of resection, it is also necessary to follow the doctor’s advice for regular review. Most people do not know enough about the disease and think that high-grade neoplasia is not cancer, so they do not have regular checkups, which leads to the progression of cancer and regret. Therefore, it is necessary to raise the awareness of the disease. Bowel polyp foci indicate that high-grade endothelioma is precancerous, and it is necessary to actively cooperate with the doctor’s treatment in order to achieve the goal of early detection and early treatment.