Liver palms are mainly due to estrogen inactivation disorder, mostly considered to be caused by hepatitis, cirrhosis and other liver diseases, and patients may also show weakness, loss of appetite, epigastric pain, anorexia, diarrhea and so on. Liver palms are obvious pink congested spots or plaques on the palms of the hands at the level of the big fish margins, small fish margins, and the abdomen of the fingers. The red color may subside after pressure, and the color can be restored after lifting. It is a characteristic manifestation of chronic liver diseases such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma, and is mostly due to the dilatation of small arteries caused by the obstacle of estrogen inactivation. Patients with liver palms may also show signs of liver insufficiency, such as fatigue, loss of appetite, indigestion, epigastric pain, anorexia, diarrhea, ascites, esophagogastric fundic varices, and jaundice (yellow staining of the skin and eyes, and deepening of the yellow color of the urine). When a patient develops liver palms, it is recommended that he or she seeks medical attention in a timely manner and actively undergoes treatment to avoid delaying the condition.