Osteoarthritis is one of the most common joint diseases and is a chronic joint disease characterized by degeneration and destruction of joint cartilage and osteophytes. The disease is associated with aging, obesity, inflammation, trauma, joint overuse, metabolic disorders, and genetics. Osteoarthritis is more prevalent after middle age and is more common in women than men. The prevalence of the disease is 10%-17% in people aged 40 years, 50% in people aged 60 years or older, and up to 80% in people aged 75 years or older. The disease has a certain degree of disability. Based on the above factors and age of onset of osteoarthritis, we tend to associate osteoarthritis with the elderly population, too much “labeling” and too much emphasis on the correlation between “aging” and osteoarthritis, while ignoring the “obesity, inflammation, trauma, and the disease. Obesity, inflammation, trauma, joint overuse, metabolic disorders, and genetics” play a fatal role in the development of osteoarthritis, especially in weight-bearing joints such as the knee. For a long time, for patients, they think they are young and do not take it seriously, lacking the appropriate health concept in daily life and work; avoiding the disease and losing the best time for treatment. For doctors, the early treatment of osteoarthritis in young people is neglected, and the lack of health guidance for these young patients has led to further aggravation of the disease. Therefore, it is something we have to look at dialectically, not only to see its universality, but also to see its specificity; not only to see its majority, but also to see its minority; not only to see its past, but also to predict its future. Cervical and lumbar spine disease was once thought to be a common problem of the elderly, however, today’s cell phone computer information era, white-collar workers born today’s fierce competition, cervical and lumbar spine disease has been rejuvenated, is no longer the “label” of the elderly. Of course, osteoarthritis of the knee is no exception. According to the 2010 Guidelines for the Diagnosis and Treatment of Osteoarthritis, the occurrence of osteoarthritis is associated with aging, obesity, inflammation, trauma, joint overuse, metabolic disorders and genetics. It appears that aging is only one, but not all, of the factors that influence the development of osteoarthritis, and this is confirmed in clinical practice. First, older people do not necessarily have knee pain. There are many older adults in our lives who do not have osteoarthritis of the knee. Second, it is not only the elderly who have osteoarthritis of the knee, but also countless young people. In a rough summary, you will see: little girls who love to dance, chefs who stand and sit for a long time, salesmen who run around, elementary school teachers who have a lot of experience, athletes who fight for gold and silver, fat people who are over-nourished, and “donkeys” who travel long distances …… Finally, most of the patients with osteoarthritis of the knee are obese, or are young educators or sports enthusiasts who have a record of overuse of the knee joint. Therefore, we should have a proper understanding of osteoarthritis of the knee, the process of its occurrence and development, so that we can scientifically prevent the occurrence of osteoarthritis of the knee and control the development of osteoarthritis of the knee with reasonable treatment to improve and enhance our quality of life.