Can’t stop coughing at night, many reasons, often considered to be pneumonia, cough variant asthma, etc., need to improve the examination to clarify the cause of the disease, and actively carry out drug treatment. 1. Pneumonia: The cough is worse at night and may be caused by mycoplasma infection. After a clear diagnosis, you can follow the doctor’s instructions to take macrolide antibiotics, such as erythromycin, azithromycin, etc., and at the same time use cough suppressants, such as codeine oral solution. If there is phlegm in the later stage, Ambroxol can be used to resolve the phlegm. 2. Cough variant asthma: related to allergen stimulation, airway hyperresponsiveness, may appear at night coughing more severe symptoms, it is recommended to improve the lung function, lung CT, serum antigen and antibody tests to clarify the diagnosis. For patients with cough variant asthma, bronchodilators such as terbutaline and glucocorticoids such as budesonide can be nebulized. Antiallergic drugs such as montelukast sodium and dicloretadine can also be given. Unstoppable cough more severe at night, may also be due to other diseases, such as cardiac insufficiency, gastroesophageal reflux stimulation, upper airway cough syndrome, etc., should be early to seek medical attention, clear the cause of the disease, and then comply with the doctor’s prescription of medication to avoid delays in the condition. Drink plenty of water during treatment and do not eat spicy and stimulating food. The above medications should be used under the guidance of a physician.