Stomach may still hurt during H. pylori treatment. Stomach pain may also occur during treatment due to reasons such as uncontrolled disease. However, stomach pain may also be caused by irritation of the gastric mucosa with medication. If stomach pain occurs, patients are advised to go to the hospital for a follow-up examination. Helicobacter pylori infection can appear bloating, belching, intermittent abdominal pain and discomfort, acid reflux and other symptoms. Stomach pain may also occur during early treatment when the medication is not fully effective or when the disease is not under control. By strictly following the doctor’s instructions and actively cooperating with the doctor’s treatment, the patient’s symptoms will gradually be relieved. In addition to stomach pain caused by H. pylori infection, stomach pain may be caused by improper use of medication. The medication for H. pylori infection is irritating to the stomach and may cause stomach discomfort, so it is recommended to take the medication after meals. If the stomach pain is severe or the symptoms do not improve, it is recommended that the patient go to the hospital for a follow-up examination to clarify the cause of the disease.