In general, the use of medication can be effective in about 1 week. However, the extent of the disease varies from patient to patient, so the effect of use varies from person to person. Minocycline Hydrochloride for acne treatment lasts for 6 to 8 weeks, depending on the patient’s condition, and the effect of acne treatment is more rapid and significant. In general, after the use of obvious therapeutic effects, such as the inflammatory area darkened, crusting, you can suspend the use of minocycline hydrochloride, the use of topical drugs to adhere to the application of maintenance treatment. If the symptoms do not improve after 6 to 8 weeks of use, or if new acne appears, the treatment can be adjusted with medications such as erythromycin or doxycycline. Adverse reactions are common in gastrointestinal symptoms, such as abdominal pain, nausea, anorexia, etc. In severe cases, it may cause shock and allergic-like reactions, but also includes acute renal failure and interstitial nephritis, etc. Pay attention to the observation during the use of medication, and consult the doctor in time when there are abnormal manifestations. It is recommended to use the drug under the guidance of a doctor, liver and kidney insufficiency, pregnant and lactating women should not use. When taking minocycline, pay attention to a light diet, regular life, avoid fishy and spicy stimulating food.