Forty-something men to extend the time of sex life can be local medication, oral medication, psychotherapy, behavioral therapy and so on. 1. Local medication: you can apply lidocaine gel locally before sex, which is a kind of local anesthesia drug that can reduce sensitivity and prolong sex time. It is necessary to pay attention to the side effects and adverse reactions of the drug, please use the above drugs under the guidance of a doctor. 2. Oral medication: selective 5-hydroxytryptamine reuptake inhibitors, such as dapoxetine, can be taken orally under the guidance of a doctor. It is necessary to pay attention to the side effects and adverse reactions of the drugs, please use the above drugs under the guidance of a doctor. 3. Psychotherapy: Psychotherapy is mainly to help men develop sexual skills, enhance the patient’s confidence, reduce anxiety, and pay attention to improve the couple’s relationship. 4. Behavioral therapy: Behavioral therapy is mainly to reduce sensitivity through some behavioral therapies, including extrusion method, stop-action method and so on. Men in their forties who need to prolong their sex life need to be treated under the guidance of a doctor, and all of the above medications should be used under the guidance of a doctor, not blindly used on their own.