The human skull exists to protect the brain, the central command of the human body, and to a lesser extent, the bony scaffolding of the orbit, nasal cavity, mouth and face. If there is a defect in the skull, it will not only deprive the brain of its hard protective shell, but also affect the patient’s image, so when there is a defect in the skull, skull repair surgery should be done as soon as possible. In addition to the hard skull material that can effectively prevent the brain from being hit by external forces, skull repair also helps to improve the problems such as impaired blood supply to the brain and abnormal cerebrospinal fluid circulation. The longer the cranial defect, the higher the incidence of cranial defect syndrome and secondary brain damage. Moreover, craniosynostosis also leads to a change in the shape of the cranial defect area, and the scalp is affected by atmospheric pressure, which makes it invaginate and compress the brain tissue. Therefore, in order to restore the cranial cavity confinement, maintain the physiological intracranial pressure stability and reduce the cranial defect syndrome. Therefore cranial bone repair should be done as early as possible after cranial defect to avoid the above symptoms, which threaten the health of patients. In addition, cranial repair is particularly important in the selection of materials. The most ideal material for cranial repair is the new PEEK material, which is a new type of polymer material with good histocompatibility, and patients are not prone to infection or rejection after surgery. Therefore, the peek material is the preferred better material for patients.