If there are hard lumps after one week of hyaluronic acid injection, the hard lumps can be softened by conservative observation, topical medication and dissolving enzyme injection. 1. Conservative observation: generally after hyaluronic acid injection, there will be local hard lumps in the short term, which can not be ruled out that it is caused by uneven injection or local hematoma, and usually it will be softened and disappear in about 1-2 weeks. 2. Topical drug treatment: if the local hard lump is caused by bacterial infection, often accompanied by redness, swelling, heat and pain in the filling area, it can be treated with antibiotic ointment, such as erythromycin ointment, mupirocin ointment and so on. 3. Dissolving enzyme injection: If the local hard lumps can not be eliminated by themselves for a long time, then the local injection of dissolving enzyme can dissolve the hyaluronic acid and decompose it into small molecules, and the local hard lumps will disappear. It is recommended that patients according to their own situation, if necessary, go to a regular hospital, follow the doctor’s instructions to standardize the treatment, not blindly self-medication, so as not to cause adverse consequences.