Chronic atrophic gastritis C2 with erosion indicates that atrophy of the gastric mucosa has involved the gastric antrum and the lower lesser curvature side of the gastric body. Generally, antimicrobial treatment, medication and surgery can be taken to deal with it. 1. General treatment: patients suffering from chronic atrophic gastritis C2 with erosion can regulate their diet in their daily life, choose easily digestible and light food, avoid spicy stimulation and greasy food intake, avoid overeating, and try to avoid staying up all night. 2. Medication: If accompanied by Helicobacter pylori infection, it is necessary to use quadruple therapy for eradication, i.e. one proton pump inhibitor, one bismuth agent and two antibiotics, commonly used are clarithromycin, amoxicillin, bismuth potassium citrate, omeprazole and so on. Drugs such as magnesium aluminum carbonate can also be used to protect the gastric mucosa. It is recommended that patients with chronic atrophic gastritis C2 with erosion should go to the hospital in time and be treated accordingly under the guidance of the doctor.