I. Diagnosis can be diagnosed if the following 4 items are met (1) Meet the revised criteria for diagnosis of SLE proposed by ACR in 1998. (2) The disease is in the active stage. (3) The presence of convulsions or other neuropsychiatric symptoms, excluding those caused by other diseases. (4) Cerebrospinal fluid examination: mildly elevated leukocytes and protein, no significant decrease in sugar, positive ANA. When diagnosing, pay attention to exclude intracranial infection based on clinical manifestations, imaging, cerebrospinal fluid examination and body fluid culture. Treatment 1. Symptomatic management (1) Persistent status epilepticus: use Valium 10-20mg/time by sedation and Luminazepam 0.1-0.4g by intramuscular injection. (2) Manic schizophrenic-like symptoms: use Haloperidol 5-10mg by intramuscular injection, 1-2/day or Fenadrine 2-4mg by oral injection 1-3/day, use Antan 2mg orally 2 times/day to counteract extrapyramidal symptoms. (3) Cerebral hemorrhage: small and deep hemorrhage should be treated conservatively by maintaining normal blood pressure and rapidly correcting abnormal coagulation status, while large hemorrhage (>40ml) and those with significant occupying effect need urgent craniotomy and decompression surgery. (4) Coma: tilt the head slightly forward when lying down, favor one side, aspirate regularly, keep the airway unobstructed, and give mechanical assisted breathing if necessary. (5) Hyperthermia: Perform blood culture, C-reactive protein test, cerebrospinal fluid examination (culture, ink stain and antacid stain, etc.), actively implement physical cooling, such as alcohol bath, etc. If the body temperature exceeds 38.5℃, use antipyretic drugs such as paracetamol or non-steroidal anti-inflammatory drugs, etc. Combined with cerebral edema, the hyperthermia will be normalized by using dormant combination with physical hypothermia. (6) Cerebral edema: actively dehydrate and lower the pressure, the amount of water out is slightly more than the amount of water in (water in = previous day’s urine + 500ml), if the renal damage is not serious, use 20% mannitol 250ml, injected quietly, 20-30 minutes, and then 1 time/6-8h, if the renal damage is serious, use dexamethasone 5-10mg, tachyphylaxis 40-200mg + 50% glucose 100ml, 1 time /6-8h, intravenous push. To prevent and treat stress ulcers, use 100ml of ice saline with norepinephrine 8mg, orally or intranasally or metformin 0.2-0.4g2/day as a sedative. 2, treatment of primary disease: methylprednisolone plus cyclophosphamide shock: methylprednisolone 0.5-1.0g plus saline IV, 1 time / day for 3 days, the fourth day with cyclophosphamide 0.6-1.0g shock 1 time, after that change to oral prednisone 40-60mg / d. At the same time with methylprednisolone can be used immunoglobulin shock 400mg / (kg, d), a total of 3-5 days . For patients with lupus encephalopathy without lupus activity and intracranial infection, or patients with lupus encephalopathy with extracranial infection not easily controlled and not suitable for high-dose glucocorticoids, intrathecal methotrexate 10-20mg + dexamethasone 10-20mg (dissolved and diluted in 3ml of saline) can be used for slow injection at an interval of 7 days each time, no more than 3 times.