There is no such thing as the 5 worst manifestations of premature ovarian failure, which is early onset ovarian insufficiency, with common symptoms such as amenorrhea and infertility. Early onset ovarian insufficiency refers to the loss of normal function of the female ovaries before the age of 40. Patients will experience menstrual abnormalities in the early stage, including scanty, frequent or amenorrhea. Depending on the time of onset, it may present as primary or secondary infertility. Most women will also experience low estrogen manifestations, such as hot flashes, insomnia, memory loss, vaginal dryness, and decreased libido. Some women will also have accompanying symptoms, such as osteomalacia, which may lead to sudden fractures in daily life. For women with early-onset ovarian insufficiency, they should seek medical treatment in time and cooperate with doctors for standardized treatment to improve the symptoms. Daily need to rest more, avoid overwork, regulate bad mood, so as not to be overly emotional. Appropriate sports and exercise to enhance physical fitness.