Lenopril hydrochlorothiazide acts as a vasodilator, reduces blood volume, and has a hypotensive effect. Adverse reactions include thirst and weakness and dizziness. Lenopril hydrochlorothiazide is a compound preparation, including two ingredients, lynopril and hydrochlorothiazide. Lenopril has the effect of vasodilatation, and hydrochlorothiazide’s mechanism of action is diuretic, and the combination of the two can increase the effect of antihypertensive, especially suitable for antihypertensive treatment in patients with cardiac insufficiency. The adverse reactions of Lenopril hydrochlorothiazide include dizziness, headache, cough, fatigue and postural hypotension. It is contraindicated in patients with hypersensitivity to drug components, severe renal insufficiency, lactating pregnant women, those who have experienced angioedema after ACE inhibitor therapy, those with hereditary or congenital angioedema, anuric patients, those who are allergic to sulfonamides, and those with bilateral renal artery stenosis. Lenopril hydrochlorothiazide for the treatment of hypertension should be used under the guidance of a physician, to master the adverse reactions and contraindications of the drug, and should not be taken on their own.