Antinuclear antibody 1:100 means positive antinuclear antibody, homogeneous type is one of the fluorescent karyotypes of antinuclear antibody, nuclear antibody 1:100 homogeneous type can be seen in normal people, rheumatoid arthritis, infectious mononucleosis and other conditions. Antinuclear antibody is a general term for a class of autoantibodies that target the nuclear components of cells and nucleic proteins and nucleic acids in the cell plasma. Antinuclear antibody should normally be negative or have a titer of less than 1:40, while antinuclear antibody 1:100 is a low-titer positive antibody, which can be seen in normal people and the older the person, the higher the rate of positivity. Antinuclear antibody positivity can also be seen in rheumatoid arthritis, systemic lupus erythematosus and other rheumatoid immune diseases and infectious mononucleosis and other non-rheumatic immune diseases, patients need to further improve the CRP, autoantibodies, sedimentation rate and other related auxiliary tests to exclude disease factors caused by the abnormal antinuclear antibody test. Laboratory test results should be interpreted by a professional physician, and it is recommended to go to the rheumatology and immunology department of a regular hospital for detailed consultation and standardized treatment according to the doctor’s instructions.