The condition of large hard bumps on the face is considered to be related to cystic acne and nodular acne, which can be relieved by medication and surgery. 1. Cystic acne: This is a more serious type of acne, belonging to severe acne, and the treatment mainly focuses on improving the condition of the skin lesions. It can be treated with medications such as minocycline, doxycycline, and isotretinoin, which can inhibit the secretion of sebum from sebaceous glands and regulate the abnormal keratinization of sebaceous ducts in hair follicles. When the infection is more serious, incision and drainage can also be chosen to treat. 2. Nodular acne: This is also one of the types of acne, like cystic acne, the treatment is mainly based on anti-inflammatory treatment, you can cooperate with the doctor to choose amoxicillin, azithromycin and other drugs. You can also cooperate with your doctor to choose surgical excision, so as to improve the local appearance. It is recommended that after the symptoms of large hard lumps on the face, patients should be based on their own situation, follow the doctor’s advice to choose the appropriate treatment and treatment, not blindly use drugs.