Sex hormone binding globulin, also known as testosterone-estradiol binding globulin, plays an important role in the action of female sex hormones. Decreased values are often seen in obesity, polycystic ovary syndrome, hypothyroidism and other disorders that require a clear diagnosis. 1. Obesity: Obese women usually have higher serum insulin levels, and insulin can inhibit the production of sex hormone globulin by the liver, resulting in low blood levels of sex hormone globulin. 2. Polycystic ovary syndrome: one of the more common diseases in the gynecological reproductive endocrine system, which can lead to thyroid hormone secretion disorders, causing estrogen and sex hormone globulin secretion disorders, thus leading to low sex hormone globulin. 3. Hypothyroidism: it is a systemic disease caused by insufficient secretion of thyroid hormone, which will lead to a decrease in the level of testosterone-estradiol binding globulin. It is recommended that the patient go to the hospital and undergo relevant examinations. Follow the doctor’s instructions to use medication, not unauthorized use of medication treatment.