Just as there is good and evil in people, there is also good and evil in cholesterol. Choosing the right team is choosing the right good and evil, one thought is the devil, one thought becomes the Buddha, that is to say, this HDL cholesterol is with the right leader, and thus grow into a “good” cholesterol. As we said earlier, LDL cholesterol is the truck that transports the dirt from the construction site to the outside, while HDL cholesterol is like a garbage truck that transports the scattered garbage cholesterol back to the liver for recycling. Therefore, HDL cholesterol has an anti-atherosclerotic effect. Remember the name of this “good” cholesterol, which is sometimes found on our labs under the abbreviation “HDL”. In 1985, Drs. Brown and Gustin from the United States presented a new perspective on the mechanism of lipoprotein metabolism: HDL, an apolipoprotein inherent in human blood, drives the reverse transport of cholesterol, and by doing so, carries excess cholesterol and other “blood waste” from blood and tissues through the liver to be broken down and reversed. “HDL has many functions such as reversing endothelial dysfunction, stimulating prostacyclin production (which has vasodilating and antithrombotic effects), inhibiting endothelial cell apoptosis, reducing platelet aggregation, and inhibiting LDL oxidation. This theory laid the theoretical foundation of lipoprotein metabolism, and the importance of HDL in the physiological organism was again brought to a very important position. Especially because of the outstanding contribution of these two doctors, they were awarded the Nobel Prize in Medicine in that year. The deep scientific mystery underneath the theory and the glowing social honor immediately attracted many people, and various researches were carried out almost simultaneously in all continents of the world, and HDL became a bright pearl on the top of Mount Everest. The discovery of HDL metabolic theory is an atomic bomb in the world medical history, his explosive force and shock wave, rippling for decades, many people vomited their hearts and souls for a lifetime, because we all know clearly – who can significantly raise HDL, who will solve the problem of coronary heart disease or even the entire cardiovascular disease, who will be able to human life expectancy by decades in theory.