The skull builds a defense wall for the brain tissue, which protects the brain tissue from external aggression, but many reasons in life may lead to cranial injury, such as falling objects, traffic accidents, or the presence of craniosynostosis and have to do surgery to remove large bone flaps, may leave the problem of cranial defect, once the cranial defect occurs, the next will face more injuries. For example, the intracranial pressure and intracranial environment will become very unstable after cranial defect, and cerebrospinal fluid circulation and blood circulation can be affected, which will cause a series of cranial defect syndrome, mainly manifesting as headache, vertigo, nausea and vomiting, epilepsy, irritability, etc., and various mental disorders can occur. The effects of cranial defects cannot be ignored, and timely cranial repair surgery in hospital is the key. In the cranial repair surgery, the choice of repair material is crucial, which is an important factor affecting the outcome of the surgery. Hydroxyapatite is a cranial repair material that was used decades ago, but is no longer used in clinical practice because of various problems. The PEEK material currently used by our team has additional advantages. It is a very advanced polymer material that makes up for the shortcomings of various traditional materials, and it has excellent properties in all areas. In addition, we also incorporate cosmetic techniques into the surgery, which results in a more natural-looking outcome.