The causes of SLE are complicated and may be related to family genetics, endocrine factors, viral infections, environmental factors and other factors. 1. Family genetics: SLE has family aggregation, and people with a family history of SLE are more likely to suffer from the disease. 2. Endocrine factors: Clinical studies have found that the occurrence of SLE may be related to estrogen, prolactin, growth hormone and other hormones. 3. Viral infections: EBV infection, endogenous retrovirus, cytomegalovirus infection and other viral infections are also associated with the development of SLE. 4. Environmental factors: Ultraviolet radiation can induce or aggravate the skin manifestations of SLE. SLE is often characterized by multi-organ and multi-system involvement and requires early treatment if diagnosed. It is recommended that SLE patients go to the rheumatology and immunology departments of regular hospitals for detailed consultation.