Testicular pain treatment involves the use of different medications depending on the cause of the pain. The common causes of testicular pain include orchitis, epididymitis, varicocele, epididymal cyst, and testicular trauma. Orchitis and epididymitis are clinically similar and can be categorized as acute and chronic. In the acute stage, in addition to pain in the scrotum, it is also accompanied by redness and swelling of the scrotal skin, and may be accompanied by systemic symptoms such as fever, chills, etc. It is necessary to use sensitive antibiotics for symptomatic treatment, and the commonly used medications include cephalosporins or quinolones. Varicose veins can cause scrotal swelling and pain when the sexual urge is frequent or the degree of varicose veins is more serious. In the early stage, it can be relieved by taking Mazolin orally, in addition to improving the life style, such as wearing scrotal support underwear, etc. Surgery is needed when it is necessary. Epididymal cysts usually have no symptoms in the early stage, but in larger cases, they may cause pressure symptoms and testicular discomfort or pain. Testicular pain caused by scrotal trauma is an emergency and needs to be treated promptly. To summarize, medication for testicular pain depends on the cause of the pain. Pain caused by epididymitis or orchitis can be restored after antibiotic treatment, and conservative treatment of varicocele can also be effective in the early stages.