Treatment of ureaplasma deconjugatum infection is based on antibiotic therapy. Ureaplasma urealyticum is a common pathogen that causes nongonococcal urethritis. Drug therapy is still the mainstay of treatment. The majority of Ureaplasma urealyticum infections are sexually transmitted, and a few are due to close living contact. The symptoms of non-gonococcal urethritis caused by Ureaplasma urealyticum are often accompanied by painful urination and urethral discharge, which is yellowish or purulent in color, and sometimes accompanied by leucorrhoea in women, etc. 20%~50% of the population do not have obvious clinical symptoms, and are often detected by physical examination. Currently, treatment is based on the use of appropriate and sensitive antibiotics against the pathogenic bacteria. Generally speaking, macrolide antibiotics are preferred, such as azithromycin or roxithromycin. With the continuous emergence of drug-resistant bacteria, the choice of antibiotics is also changing and upgrading. In addition to the application of antibiotics, general treatment such as drinking plenty of water and keeping clean are also important. To summarize, the treatment of Ureaplasma urealyticum infection is still based on antibiotic treatment, before treatment, we need to identify the pathogenic bacteria infection and do drug sensitivity test, timely symptomatic treatment, of course, the treatment and prevention should be emphasized, the patient’s towels, underwear or bath tubs should be separated, and sexual partners also need to be treated at the same time.