The main differences between HPV (Human Papillomavirus) 4-valent and 9-valent are the types of viruses and diseases to be prevented, the price, and the applicable age. Women who are suitable for HPV vaccination can take into account their own needs and conditions and receive the appropriate HPV vaccine under the guidance of their doctors. 1. Preventing viruses and diseases: HPV4-valent is mainly used to prevent HPV6, 11, 16 and 18 viruses, which can prevent cervical cancer and condyloma acuminatum; while HPV9-valent can prevent the above mentioned viruses as well as HPV31, 33, 45, 52 and 58 viruses, and it can also have certain preventive effect on vaginal cancer and anal cancer. 2. Price: The price of HPV 4-primary triple vaccine is about 2,500 RMB; while the price of HPV 9-primary triple vaccine is about 3,900 RMB or even higher, and it is more difficult to make an appointment. 3. Applicable age: The suitable age for HPV4 vaccine is 9~45 years old, while the suitable age for HPV9 vaccine is 16~26 years old. In the period of pregnancy, breastfeeding, acute fever of disease or allergy to vaccine components can not be inoculated with the nine-valent vaccine, but also need to pay attention to some of the adverse reactions of the vaccination such as injection site pain, redness, swelling, headache, etc., so the injection needs to be followed by the doctor’s advice to observe for a period of time before leaving. After the HPV vaccination, it does not prevent 100% of HPV infection, and you should also have regular rechecks for HPV and TCT (Liquid-based Thin Layer Cytology Test).