Full moon face can be seen in long-term use of hormones, pituitary Cushing’s disease, adrenocortical carcinoma, ectopic ACTH syndrome, etc. Treatment should be based on the cause of the disease, including medication and surgery. 1. Long-term use of hormones can cause full-moon face and buffalo back, and the intake of hormone drugs such as prednisone can be reduced under the guidance of doctors. 2. Pituitary Cushing’s disease causes full moon face, mainly to maintain normal weight, pay attention to rest, healthy diet. And actively and timely surgery to remove the pituitary lesion. 3. Adrenocortical carcinoma causes full moon face due to increased glucocorticoid level, surgical resection is the first choice, if metastasis occurs, bromocriptine, metipranolone and other drugs can be taken. 4. Ectopic ACTH syndrome can be seen in lung cancer and thymus cancer, which requires active treatment of the primary disease, such as surgical resection of the tumor, or use of carbamazepine, bromocriptine and other drugs to inhibit the synthesis of glucocorticoids. Full moon face is a description of facial obesity, which belongs to pathological changes. Once found, it should seek medical consultation in time to find out the cause and be treated under doctor’s guidance.