Newborns may have the disease if their mothers do not have lupus erythematosus because lupus erythematosus is not only related to genetic factors, but also to abnormalities in immune regulation, ultraviolet irradiation, allergies, and infections. Lupus erythematosus is a chronic autoimmune disease mainly characterized by butterfly-shaped erythema. It is not only related to genetic factors, but also may be related to allergic constitution, abnormalities in immune regulation, ultraviolet irradiation and infections, etc. Therefore, even if the parents don’t have lupus erythematosus, the newborns may get lupus erythematosus if they are affected by the internal or external environment and so on. Parents need to go to the hospital for relevant examinations in time when they find their newborns have lupus erythematosus, and actively treat the symptoms after clarifying the cause of the disease.