Helicobacter pylori infection is the causative factor for most gastric ulcer patients, so gastric ulcer is related to Helicobacter pylori. H. pylori will destroy the barrier of the gastric mucosa and increase the body’s secretion of gastrin, which in turn causes a series of gastric diseases. Gastric ulcer about 60-90% of patients have H. pylori infection. For Helicobacter pylori infection gastric ulcer, it is recommended to actively anti-Helicobacter pylori treatment, commonly used quadruple therapy treatment, which includes omeprazole capsules, clarithromycin, metronidazole, bismuth pectin and other drugs. If the ulcer area is relatively large and there is H. pylori infection, it is also necessary to rule out whether it is gastric cancer, if the biopsy is benign, the treatment must be regularly rechecked gastroscopy and H. pylori. When gastric ulcer occurs, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, and choose a reasonable treatment plan under the doctor’s comprehensive analysis.