Sodium bicarbonate medication has certain side effects, mainly the following four points: First, sodium bicarbonate tablets react chemically with gastric acid to produce water and carbon dioxide, and the prolonged gathering of carbon dioxide in the stomach can cause secondary increase in gastric acid or belching. Secondly, since sodium bicarbonate drug is irritating, nausea, vomiting and stomach pain may occur for the organism with sensitive and fragile gastrointestinal tract. Third, if the body takes too much sodium bicarbonate drugs, it will lead to an increase in the concentration of sodium ions in the body. Fourthly, long-term consumption of sodium bicarbonate tablets will synthesize the stomach acid, which can reduce the acidity of the stomach and make it easy for the gastrointestinal tract flora to migrate and thus infection to occur. In the clinic, taking the drug should be strictly according to the doctor’s instructions for symptomatic use to avoid uncomfortable symptoms, and drink more water after taking the drug to reduce the occurrence of side effects.