Pain at the root of the big toe and the joint of the foot may be caused by trauma, arthritis, tenosynovitis, metatarsalgia and other factors. 1. Trauma: If the patient has strenuous activities on the foot or suffers a blow in this area, sprains and contusions at the joints can occur, or even fractures and other injuries. This can lead to pain. 2. Arthritis: If the patient has autoimmune disease or suffers from gout, rheumatoid arthritis or gouty arthritis can occur in the joints. This can cause pain. 3. Tenosynovitis: If the patient walks too much or wears ill-fitting shoes, it may cause excessive friction between the flexor tendons and tendon sheaths of the metatarsophalangeal joints. This may cause tenosynovitis, which in turn causes pain. 4. Metatarsalgia: This disease is due to the pain caused by the strain of the transverse arch of the forefoot or the compression of the plantar phalangeal nerve, and the pain can be relieved after rest. The pain at the root of the big toe and the joint of the ball of the foot may also be caused by other factors, the patient should go to the hospital in time for examination, to clarify the cause of the disease and then carry out appropriate treatment.