Herpes blisters on the hands, may be sweat herpes, or herpes zoster, etc. According to the cause of the disease to choose the appropriate medication for treatment. 1. Sweat herpes: the cause of the disease is unknown, usually seen on the palm surface, finger side and other parts of the transparent blisters, accompanied by itching. Glucocorticoid drugs such as tretinoin cream can be used externally; if the itching symptoms are severe, antihistamine drugs such as loratadine can be taken orally as prescribed by the doctor. 2. Herpes zoster: often caused by the activation of varicella zoster virus, most often seen on the hands of unilateral clustered blisters. You can take oral acyclovir tablets and other antiviral drugs under the guidance of a doctor, and use antiviral creams, such as penciclovir cream, at the same time. Herpes hand blisters may also be caused by other diseases, it is recommended that patients go to the hospital in time to do the relevant examination, a clear diagnosis, for the cause of the treatment, do not blindly use their own medication.