It is advisable to go to the hospital for an examination to clarify the cause of a bump on the male genitalia. The first is often seen after unclean sexual contact, infected with human papillomavirus. It is a good idea to have a local excision to confirm the diagnosis, as the surface is not smooth and the color is red with bleeding and pain, or with abnormal discharge and smell. Secondly, penile cancer can be manifested as cauliflower-shaped lumps on the glans and foreskin, accompanied by local pain and bleeding. The volume may gradually increase, the scope may gradually deepen, and it is accompanied by obvious bleeding and pain. Local biopsy is needed to further confirm the diagnosis of penile cancer. Thirdly, pearly papules of penis may exist around the coronal groove of glans or on both sides of the prepuce, showing papilla-like or granuloma-like growths. They are soft in texture, without pain and secretion, and can exist for a long time without any change in volume and size.