Mesenchymal tumors of the duodenum gastrointestinal tract are mesenchymal tumors that grow in the duodenal region of the gastrointestinal tract as a result of non-directional differentiation of mesenchymal tissues in the gastrointestinal tract. Mesenchymal tumors of the duodenum are most commonly found in the descending and horizontal portions of the duodenum. The tumors are classified into 4 risk classes according to their size and the number of nuclear divisions. Tumors with a size of ≤2 cm and a nuclear division number of ≤5 are generally considered benign. The most common manifestation of duodenal mesenchymal tumor is gastrointestinal bleeding, which may be accompanied by nausea, vomiting, abdominal pain, etc., and some patients may also have symptoms of intestinal obstruction. Surgical resection can be adopted for treatment, and targeted therapy can be carried out according to the situation. It is recommended to go to the hospital in time to clarify the cause of the disease when the corresponding symptoms appear, standardize the treatment under the doctor’s prescription, actively cooperate and maintain healthy living habits.