The phenomenon of increased thyroglobulin is very common in the clinic, and is generally attributed to the following reasons: 1, there are certain inflammatory changes in the patient’s thyroid gland, such as clinical lymphocytic thyroiditis, subthyroiditis, suppurative thyroiditis, and high-functioning adenomas, and these inflammatory or adenomatous diseases, so that the thyroid gland suffers from destruction. The rupture of thyroid follicles will cause the release of thyroxine into the blood, which will stimulate the body to produce thyroglobulin antibodies, and the phenomenon of elevated thyroglobulin will occur.2. It is found in the clinic that some thyroid tumors, including malignant thyroid carcinoma, papillary medullary carcinoma and so on, after destroying the thyroid gland, the thyroglobulin will be increased as well. Therefore, if the phenomenon of increased thyroglobulin occurs, the symptom must not be neglected, and it is necessary to review thyroid ultrasound and corresponding examination to find out the exact cause of the disease, and then carry out systematic and standardized treatment according to the cause of the disease.