The main symptoms of hypokalemia include muscle weakness, muscle paralysis, cardiac arrhythmias and ECG abnormalities, and affected renal function. 1. Muscle weakness and muscle paralysis: Hyperpolarization of skeletal muscle cell membrane caused by hypokalemia can affect the depolarization of cells, leading to contractile dysfunction. It is manifested as weakness and even muscle paralysis. Severe cases can cause diaphragmatic paralysis and respiratory failure. Hypokalemia can also cause skeletal myopathy and rhabdomyolysis. Hypokalemia can also cause paralytic intestinal obstruction, affecting oral potassium supplementation. 2. Arrhythmia and electrocardiogram abnormality: Hypokalemia can depolarize the conduction system of the heart, so arrhythmia is a serious complication of hypokalemia. Patients with long-term chronic hyperkalemia such as those using diuretics are prone to supraventricular and ventricular arrhythmias during stressful situations such as traumatic brain injury, acute coronary syndrome, and myocardial ischemia. Chronic hypokalemia cardiac depolarization leads to electrocardiogram showing wide and low flat T wave, and U wave if the depolarization is prolonged. 3. Impact on renal function: Hypokalemia increases ammonia production in the proximal renal tubules, increases bicarbonate reabsorption and net acid excretion, leading to metabolic alkalosis. Potassium deficiency causes decreased expression of the water channel protein AVP on the luminal membrane of the collecting ducts, causing secondary nephrogenic urolithiasis. Renal histologic changes due to hyperkalemia include proximal tubular vacuolar degeneration, interstitial nephritis, and renal cysts. If you have such problems, you should seek medical treatment as soon as possible, and during the treatment period, you need to review the blood routine and electrolytes regularly, and you should pay attention to supplementation in your daily life.