Early five-year survival rate of duodenal adenocarcinoma is above 90%, often with better prognosis. Early surgical resection of duodenal adenocarcinoma can achieve a high probability of cure because the tumor load is small, and timely surgical resection can completely kill the tumor cells. Even in early stage, some patients will have recurrence and metastasis, so they should pay attention to timely review and early treatment. As the symptoms of duodenal adenocarcinoma are not obvious in the early stage, it is often difficult to diagnose clinically, and most of the patients are found by physical examination, so the high-risk group should pay attention to screening. Therefore, patients should pay attention to screening for high-risk groups. Therefore, early treatment of duodenal adenocarcinoma often has better effect, but patients also need to have regular review.