A pimple in the middle of the nose that doesn’t go away may be a skin disease such as folliculitis, common warts or sebaceous cysts. You can use topical povidone-iodine disinfectant, antibiotic cream, freezing, laser treatment or surgical excision. 1. Folliculitis. Bacterial infection caused by the skin disease, manifested as red pimples, can have pustules at the top, with pain, local topical povidone-iodine disinfectant, fusidic acid cream or mupirocin ointment. 2. Common warts. This is a skin disease caused by viral infection, manifested as skin color or brown pimples, can be treated by liquid nitrogen freezing, laser and other methods. 3. Sebaceous cysts. It is a hemispherical cyst-like mass with a fluctuating sensation. It can be surgically removed and pathologically examined. The drugs mentioned above need to be used under the guidance of a doctor. A pimple in the middle of the nose that doesn’t go away can be seen in the dermatology department.