Early symptoms of syphilis in men are usually characterized by a chancre of syphilis. Two to four weeks after sexual misconduct, small erythematous spots and pimples appear on contact areas such as the coronal groove, prepuce, glans and penis, or in the perianal area. The patient is usually not aware of any pain or itchiness, but within a few days they will enlarge and form a hard nodule, with necrosis of the skin surface, and ultimately form a painless ulcer one to two centimetres in diameter, which is known as the chancre. Some patients do not have obvious clinical manifestations in the early stages. Syphilis is a highly contagious and harmful disease, when the patient has high-risk behavior worried about syphilis infection or suspected symptoms should be timely to the hospital for examination and diagnosis, after diagnosis must be under the guidance of professional doctors combined with personal situation timely treatment, to avoid delaying the condition of the symptoms aggravated.