There are several possibilities for painful and itchy eyes: First, the most common is allergy, which is an allergic reaction due to allergen stimulation. Allergy just occurs when the eyes itch, and pain occurs after rubbing the eyes. It is recommended to do allergen tests and stay away from allergens. You can apply hormonal eye drops such as tobramycin dexamethasone eye drops for a short period of time and non-steroidal eye drops such as pralophine drops. Viral blepharitis, caused by the herpes simplex virus, is a viral blepharitis in which the skin of the eyelids can appear as translucent vesicles with an itchy burning sensation, and if combined with a bacterial infection it can be both itchy and painful. Chronic bacterial conjunctivitis, which can manifest as itching, burning sensation, eye stinging pain and visual fatigue, requires long-term treatment, with smear of secretions and selection of sensitive medications if necessary.