The road to scientific popularization is long, not only the general public need to update the knowledge of drug use, but also clinicians need to update the knowledge of drug use. The basic principle of scientific use of drugs is safe, effective, economic, safety is in the first place, when the use of a drug has been unsafe, elimination is inevitable, fast and cheap can not be used as a reason to continue to eat it. Here are some of the antipyretics that should be eliminated. Anacin Anacin has been used as a fever reducer since the 1920s. In 1977, it was officially banned in the United States and withdrawn from the U.S. market. It is now banned in more than 30 countries worldwide. It was eliminated as an antipyretic because it can cause serious adverse reactions. These serious adverse effects include: fatal agranulocytopenia, autoimmune hemolytic anemia, aplastic anemia; urticaria in the skin, and in severe cases, exfoliative dermatitis and epidermolysis bullosa. Commonly used anandamide-containing medicines also have heavy sensation spirit, which should also be eliminated. Painkillers, APC tablets, and PPC tablets The above three types of drugs contain aminopyralid and finasteride, which were popularized in Europe and the United States as a new type of antipyretic from 1922 to 1934. However, it was found that patients who took the drug suffered from stomatitis and sore throat, and were later found to have reduced granulocytes, which proved that aminopyralid could cause severe granulocytopenia, leading to a decline in immunity and a variety of infections. 1938, the United States decided to remove aminopyralid from the list of legal drugs. In Denmark, the drug has been completely banned since the 1930s. It is no longer found in the current U.S. Pharmacopoeia (USP34-NF29), the European Pharmacopoeia (EP6.0), or the Japanese Pharmacopoeia JP16. Finasteride was also a widely used antipyretic, and after 1953, a large increase in kidney disease was observed in many European countries, especially in Switzerland and West Germany. Investigations confirmed that this increase in kidney disease was mainly due to the use of finasteride, and after these countries took emergency measures to ban the sale of finasteride-containing medicines, the number of patients with this type of kidney disease declined significantly. Nimesulide Nimesulide is an anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic properties. At the beginning of the market this drug was used to treat chronic arthritis, pain and reduce fever. However, in recent years, there have been several reports of severe liver damage associated with the use of nimesulide, and in conjunction with these adverse reactions, the drug is now contraindicated for use as an antipyretic and in children under 12 years of age. It is used only as a second-line anti-inflammatory analgesic, i.e., when treatment with at least one other anti-inflammatory drug has failed; it is limited to the treatment of pain in chronic arthritis, pain after surgery and acute trauma, and primary dysmenorrhea. Having said that the above fever-reducing drugs should be eliminated, I guess you must be wondering which drugs can be used to reduce fever. I’m going to tell you that there are only two safe and inexpensive fever-reducing medications that are widely used around the world: acetaminophen and ibuprofen.