Eye drops are topical medications that rarely make it into the systemic circulation, so they generally have no significant effect on the c13 breath test. The c13 breath test is a breath test that detects whether the body is infected with Helicobacter pylori by breathing in and blowing out. With an accuracy rate of over 95% and being economical and non-invasive, it is the method of choice for clinical diagnosis of H. pylori infection and post-treatment review. Eye drops are medications for treating the eyes, usually for topical application in the eyes, and do not affect the patient’s respiratory function. The c13 breath test is performed by orally administering a carbon 13-labeled urease capsule, which breaks down urea after the bacterium secretes urease if H. pylori is present in the stomach. After the urea is broken down, carbon dioxide is produced, which enters the lungs with the blood and is finally exhaled. Therefore, eye drops generally do not affect the results of the breath test. Patients are advised to use eye drops under the guidance of a doctor and not to use them without authorization to avoid adverse reactions.