Occupation of the head of the pancreas is not necessarily cancer. The pancreas is an important organ in the abdomen and is divided into the head, body and tail of the pancreas. Occupation of the head of the pancreas means that there is a lesion in the head of the pancreas, which may be benign or malignant, and there is another category between benign and malignant, called junctional. Common benign lesions include pancreatic pseudocysts, pancreatic abscesses, pancreatic plasmacytoma, pancreatic mucinous cystadenoma, etc., all of which are more common benign lesions. Malignant lesions, on the other hand, are more common in pancreatic cancer. For the initial diagnosis of pancreatic head occupancy, other imaging tests should be performed to further clarify the diagnosis, such as abdominal CT, abdominal enhanced CT, and MRI. Ultrasound endoscopy has developed rapidly in recent years for the diagnosis of pancreatic lesions and has great advantages, as it can detect small tumors <5mm and can perform puncture biopsy to clarify the nature of the lesion. If pancreatic cancer is suspected, it can be combined with serological tests, such as tumor markers, which usually have an increase in CA199. Therefore, there is no need to be too alarmed when getting the preliminary diagnosis of pancreatic head occupancy, and further examination is needed to clarify the cause and standardize the treatment in regular hospitals.