In the middle of the night stomach pain diarrhea easy to sweat consider acute gastroenteritis, acute cholecystitis or acute pancreatitis and other causes. Need to clarify the cause of the symptomatic treatment, such as taking levofloxacin, magnesium sulfate, omeprazole and other drug therapy or surgical treatment. 1. Acute gastroenteritis: due to bacterial infection, improper diet and other factors that stimulate the gastrointestinal mucosa, causing patients with abdominal pain in the middle of the night, diarrhea, nausea and vomiting, sweating, etc., the first choice of quinolone drugs such as levofloxacin. You can also choose three generations of cephalosporins such as ceftriaxone and other anti-infective treatment. Avoid unclean diet. 2. Acute cholecystitis: due to bacterial infection or obstruction of the gallbladder duct, the inflammatory mediators stimulate the mucosa of the gallbladder, causing abdominal pain and diarrhea in the middle of the night, chills and fever and other symptoms. Need to use magnesium sulfate and other choleretic drugs, serious patients need to undergo surgery to remove the gallbladder treatment. 3. Acute pancreatitis: due to the patient binge drinking, a large number of alcohol to stimulate the secretion of pancreatic juice, so that the pancreas to digest itself, appear in the middle of the night suddenly abdominal pain, vomiting, sweating and other symptoms. It is necessary to follow the medical advice to use omeprazole, growth inhibitors such as octreotide and other drugs for treatment. It is recommended that patients with any discomfort should promptly go to the hospital, improve the examination, clarify the cause of the disease and then follow the doctor’s instructions to actively treat.