Lateral calf muscle protrusion, according to the specific causes of protrusion of different, clinically can take different treatment methods. First, if the calf trauma caused intermuscular bleeding, the formation of hematoma caused by muscle protrusion. At this time, the patient needs to improve the ultrasound examination as soon as possible to clarify the size and scope of the hematoma. If necessary, cut and clear the hematoma, stop bleeding thoroughly, and apply local pressure bandage to avoid progressive increase of hematoma. Secondly, if the muscle protrusion is caused by local tumor lesion in the calf, it is necessary to complete X-ray or CT examination to clarify the specific situation of the tumor lesion, and then perform surgery as soon as possible to excise the tumor, combined with local radiotherapy and systemic chemotherapy, to kill tumor cells in the body as much as possible to prolong the patient’s life.