The penultimate large tooth can definitely be extracted. All teeth in the mouth can theoretically be extracted, provided why the teeth are being extracted. It is not uncommon to see elderly patients with no teeth in their mouths, and all the teeth can no longer be on the dentition, but every tooth is important, and it is important to try not to have them extracted, because no matter what type of restorations are made, they are not as efficient at chewing as the natural teeth. There are indeed some cases where teeth cannot be extracted, such as acute inflammatory period. Extracting teeth during acute inflammatory period may lead to the spread of inflammatory infection, which may involve the whole body and cause bacteremia or even sepsis. More serious heart disease, such as myocardial infarction within six months, or particularly high blood pressure, particularly high blood sugar, these are relative contraindications to tooth extraction, it is recommended to go to the stomatology department for examination and consultation before drawing up a treatment plan for tooth extraction.