Sigmoid colon cancer combined with liver and lung metastasis is advanced stage, and survival varies from person to person. Some studies claim that the 3-year survival rate of patients with colorectal cancer combined with liver metastasis is about 29.1%; the 3-year survival rate of patients combined with lung metastasis is about 7-20%, and the prognosis of patients with simultaneous metastasis is even worse. Sigmoid colon cancer cancer is one of the common malignant tumors in digestive system with poor prognosis. Some studies claim that about 15%-25% of colorectal cancer patients have combined liver metastasis at the time of diagnosis, while another 15%-25% of patients will develop liver metastasis after radical resection of the colorectal cancer primary, and the vast majority of them (80%-90%) will not be able to obtain radical resection of the liver metastasis initially. Liver metastasis is also the leading cause of death in colorectal cancer patients. The median survival of patients with untreated liver metastases is only 6.9 months, and the 5-year survival rate of patients who cannot be resected is less than 5%, whereas the median survival of patients with liver metastases that can be completely resected is 35 months, and the 5-year survival rate is up to 30%-57%. According to some studies, the 1-year, 2-year and 3-year survival rates of patients with rectal cancer combined with lung metastases are about 64.3%,28.6% and 7.1%; and the prognosis of patients may be improved after radiotherapy and other treatments. If the metastases are resectable or potentially resectable, neoadjuvant therapy and surgery are indicated. If the metastases are not resectable, neoadjuvant chemotherapy or chemotherapy combined with targeted drug therapy, immunotherapy, etc. are needed. It is recommended to go to regular hospitals for consultation and treatment, and follow the doctor’s instructions to avoid delaying the disease.