The skull is a particularly hard piece of bone tissue in the human body and plays a key role in protecting and supporting the brain and organs of the head and face. The skull is so important that there can not be any failure, but now the skull defects such a disease is very common, once the skull defects will destroy the closure of the cranial cavity and the stability of the intracranial environment, bringing a lot of discomfort to the patient’s body. Cranial defects should be taken seriously, and it is crucial to go to the hospital as soon as possible for cranial repair surgery. However, in the cranial bone repair surgery, the choice of repair material should be emphasized, good material prognosis is better. At present, many local hospitals widely use titanium alloy mesh material, this material has its progress compared with the past, but there are some problems and shortcomings from the clinical practice. What are the adverse reactions after titanium mesh repair of the skull? After repairing the skull with titanium alloy mesh, some patients may experience infection and rejection, and the titanium alloy material wears out the scalp, which may lead to scalp ulceration and even the risk of material exposure. In addition, the molding effect of titanium alloy is not very good, and the patients are sensitive to the external hot and cold environments after the operation, which will also affect the postoperative CT MRI, and it is also easy to collapse and deform if subjected to the external force, and so on. Titanium alloy mesh repair of the skull may still be less than ideal, now there has been a better material has appeared, is the new polyether ether ketone PEEK material. This is a very safe and advanced polymer material, its performance is very excellent, the use of PEEK material for cranial bone repair surgery can be very good to avoid titanium alloy mesh material above will appear some adverse reactions. At present, PEEK material has not been commonly used in China, our team introduced this advanced material earlier, and we have a lot of experience in this area, the team not only uses PEEK material to carry out the surgery, but also constantly improve and innovate the technology, optimize the design of the material, and innovatively introduce the concept of cosmetic plastic surgery, and comprehensively carry out PEEK cranial bone repair and plastic surgery, with a more desirable effect of postoperative recovery.