There are many kinds of intravertebral tumors, and it is not easy to explain them to you. We suggest you to read the article “What is the difference between intravertebral tumors and spinal tumors? It is recommended to read the article “What is the difference between intradural tumor and spinal tumor? Generally speaking, it is a large group of diseases, which are divided into three major categories according to their locations in the spinal canal: extramedullary intradural tumors, intraspinal tumors and intradural epidural tumors. If the tumor directly invades the nerve root, it is easy to develop nerve root pain; if the tumor is born near the spinal membrane, the pain will appear later, and the sensation of limited movement and numbness will appear. Moreover, the more violent the tumor invades the blood vessels and nerves, the more severe the symptoms will be; not the closer the tumor is to the spinal cord, the more severe the symptoms will be. The spinal cord is a thin tubular nerve structure located in the spinal canal and protected by the spine. It is like a bundle of wires connecting the central nerve of the brain and the peripheral nerve tissue (see the figure below). If a tumor grows confined to the spinal cord, it becomes an intramedullary tumor of the spinal cord. Some of the more common ones are ventricular meningiomas and astrocytomas, as well as hemangioblastomas, epidermoid cysts, and cystic teratomas. Among them, ventricular meningioma is the most common intramedullary tumor, accounting for 60% of all intramedullary tumors, and people aged 30 to 60 years old are prone to get them. However, most ventricular meningiomas are benign tumors and grow relatively slowly. If surgery is performed in time, patients can recover and have a smooth life if possible. Next, there is a spinal membrane on the outside of the spinal cord, which is actually made up of several membranous structures. From the inside to the outside, the layer that clings to the spinal cord is called the soft spinal membrane; outside the soft spinal membrane is the arachnoid membrane, between which the cerebral spinal cord flows; and outside the arachnoid membrane is a thicker layer of dura mater, which is like plastic sheeting. We often refer to this dura mater as the spinal membrane. （If the tumor grows outside the spinal cord but is encased in the dura mater, it is called an extramedullary intradural tumor. This is the most common type of intradural tumor. These include mainly nerve sheath tumors and spinal meningiomas. Nerve sheath tumors occur in the nerve roots and are generally benign tumors. The typical symptom is nerve root pain followed by gradual sensory sensitization, hyperalgesia or motor limitation. After complete surgical removal, recurrence is less likely. In contrast, most spinal meningiomas grow out of the arachnoid membrane or near the dura mater. Patients will experience pain or numbness in local segments, often with late onset of nerve root pain; when the tumor grows and compresses the spinal cord, it will cause easy limb motor dysfunction, such as paraplegia or quadriplegia. If a tumor grows in this position, it is an intradural epidural tumor. For people who have had small cell adenocarcinoma of the lung, cancer cells like to set up camp in the intradural epidural. There are also lymphomas and lipomas. Intravertebral tumors in different locations (pictures from the internet) If doctors suspect intravertebral tumors, they usually use MRI and other examinations to further determine which type of intravertebral tumors the patient belongs to. In conclusion, most of the intravertebral tumors are benign, but due to the limited space of spinal cord and spinal canal, if they are not removed in time, they will also invade the nerves and blood vessels due to compression and inflammation. Therefore, intravertebral canal tumors should be actively treated surgically, especially by micro-neurosurgery techniques, to remove the tumor as much as possible while protecting the spinal cord and spinal canal.