Superficial lymph node enlargement needs to be further clarified, the most common is caused by inflammation, local soft tissue infection will appear reactive lymph node hyperplasia or enlargement, timely anti-inflammatory treatment to eliminate the root cause of the infection, lymph node symptoms can be gradually reduced. Secondly, malignant tumors, metastasis to distant organs or lymph node metastasis, patients will have obvious symptoms of primary lesions, including gastrointestinal and respiratory tumors, and some patients have leukemia or lymphoma. The first symptom is superficial lymph node enlargement, and the patient will also have fatigue, loss of appetite, weight loss, anemia and other comprehensive manifestations. The primary treatment is intravenous chemotherapy, and for patients diagnosed early, surgery is an option to remove the primary lesion. Supplementary intravenous chemotherapy in the postoperative period kills the tiny metastases and malignant tumor cells that may exist in the bloodstream, and consolidates the effect of surgical treatment.