The skull is one of the hardest bones in the human body and is an important barrier to protect the brain and soft tissues inside the skull from attack. But the skull is not indestructible, according to the research, the force limit of the skull is 200kg~500kg, and the hardness value should be between 5 and 6. If this limit is exceeded, the skull may be damaged. Cranial defect is one of the more common clinical disorders in neurosurgery. Cranial trauma is one of the common causes of cranial defects. There are many causes of cranial trauma, such as traffic accidents, production safety accidents, falling objects, falls from height, fights and brawls, etc. Cranial trauma can occur. Cranial defects are very harmful to human body, and cranial bone repair is needed after cranial defects occur. Cranial repair surgery is a routine procedure in neurosurgery, but the choice of repair material should be carefully. Most general hospitals still use the traditional titanium mesh material for skull repair, but there are some defects and shortcomings in this titanium mesh material, and some problems may occur in clinical use. There is a new and more advanced material – polyether ether ketone PEEK material, which is a special polymer material with excellent performance, comparable to human autologous cranial bone, high comfort, strong protection and good aesthetics after placement in the human body, which has become a new trend in cranial repair materials. The price of peek cranial repair material is higher than the traditional titanium mesh material, but due to its excellent performance and good effect, it is worth spending more money. Of course, good materials also need good technical support to achieve good results.