Leakage of urine at the first sneeze is mainly due to the relaxation of the pelvic floor muscles. It can be treated by general treatment, surgical treatment, physical therapy, medication and so on. 1. General treatment: patients should quit smoking and other bad habits, and treat constipation and other chronic diseases that increase abdominal pressure. At the same time, patients can improve the symptom of urine leakage at the first sneeze through conscious pelvic floor muscle training. 2. Surgery: When the condition of urine leakage with sneezing is more serious, it can be treated by surgery, such as mid-urethral suspension. 3. Physical therapy: such as biofeedback, electrical stimulation, etc., through these methods to train the pelvic floor muscle function, which can improve the situation of urine leakage when sneezing. 4. Medications: Commonly used medications include Midodrine Hydrochloride, etc., which can improve the symptom of urine leakage when sneezing. The use of specific drugs should be under the guidance of a doctor. If the leakage of urine occurs when sneezing is serious, it is recommended that the patient go to a regular hospital as soon as possible, and give regular treatment under the guidance of the doctor.