The main reasons for dyspnea in late stage of lung cancer include tumor compression, pulmonary embolism, pleural effusion, etc., which can be relieved by symptomatic treatment under doctor’s guidance. 1. Tumor compression: Tumor compression or infiltration of airway will cause narrowing of airway, which will be manifested as dyspnea, which can be relieved through comprehensive anti-tumor treatment to control the lesion and relieve dyspnea. 2. Pulmonary embolism: patients with advanced lung cancer are in hypercoagulable state, it is suggested to improve the symptoms through interventional therapy or thrombolytic therapy. 3. Pleural effusion: pleural metastasis in advanced stage of lung cancer can cause pleural effusion, and when the symptoms are serious, it can be drained by thoracentesis to reduce the pleural effusion, so as to alleviate the symptoms of dyspnea. Due to individual differences, it is recommended to go to the hospital in time to clarify the cause of dyspnea and actively cooperate with doctors to receive standardized treatment.