The time of relief after nicotine poisoning is usually very much related to the dose of poisoning, the symptoms of poisoning and the individual’s liver and kidney excretory function. If the poisoned dose is not large and the symptoms of poisoning are relatively mild, mainly dizziness, headache, generalized weakness, liver and kidney functions are normal, usually the half-life of nicotine in the blood is about two hours, usually after two hours of poisoning, the symptoms begin to slowly ease. However, if the patient’s liver or kidney function is damaged or abnormal, it will seriously affect the metabolism of nicotine in the blood, so the time of relief may be 1-3 days, or more than a week in serious cases. If there are serious manifestations of poisoning, such as coma, shock, convulsions, etc., it is necessary to treat while observing the time of relief, and it is not easy to determine.